Table 2. Transcriptional alteration caused by HSP90 inhibition in NF2-deficient Schwann cells ESC-FC1801.

GO ID	Description	P	Genes (fold change up)	Genes (fold change down)
In vitro
GO:0007049/GO:0022402	Cell cycle/Cell cycle process	1.60E-46	Arhgap8, Camk2a, Cdc2l1, Cgref1, Chfr, Dusp1, Gadd45a, Mtus1, Pmp22, Ppp1cc, Rgs2, Sept4, Tex15, Usp16	2610039C10Rik, 4632434l11Rik, AC102494.1, Anapc1, Anapc7, Anln, Appl2, Aspm, Aurka, Aurkb, B230120H23Rik, Birc5, Brca1, Brca2, Bub1, Bub1b, C79407, Ccdc99, Ccna2, Ccnb1, Ccnb2, Ccnd1, Ccnf, Cdc123, Cdc14a, Cdc23, Cdc25c, Cdc45l, Cdc6, Cdc7, Cdca2, Cdca3, Cdca5, Cdca8, Cdkn3, Cenpe, Cenpf, Cenph, Cep110, Cep55, Chaf1a, Chaf1b, Chek2, Cit, Ckap2, Ckap5, Cks1b, Clspn, Cntrob, Ddx11, Dlgap5, Dscc1, E2f8, Ercc6l, Esco2, Espl1, Exo1, F630043A04Rik, Fam83d, Fancd2, Fanci, Gas2l3, Gsg2, Haus1, Haus5, Hells, Hjurp, Incenp, Kif11, Kif18a, Kif20b, Kntc1, Lig1, Lin9, Mcm8, Mdc1, Mki67, Mlh1, Mre11a, Myh10, Nasp, Ncapd2, Ncapd3, Ncapg2, Ndc80, Nde1, Nek1, Nek2, Nsl1, Nuf2, Nup43, Nusap1, Oip5, Plk1, Pms2, Pola1, Prc1, Prdm9, Psrc1, Pttg1, Racgap1, Rad50, Rad51, Rad51c, Rbbp8, Rbl1, Sass6, Sept10, Sept3, Sept6, Sept9, Sgol1, Sgol2, Ska1, Smc2, Spag5, Spc25, Steap3, Stmn1, Suv39h1, Suv39h2, Tacc3, Tial1, Timeless, Tpx2, Top2a, Trip13, Ube2c, Uhrf1, Wee1, Zfp318, Zwilch
GO:0051301	Cell division
GO:0007059	Chromosome segregation
GO:0048285	Organelle fission	3.77E-29	Chfr, Fis1, Usp16	2610039C10Rik, AC102494.1, Anapc1, Anapc7, Anln, Aspm, Aurkb, Birc5, Bub1, Bub1b, C79407, Ccdc99, Ccna2, Ccnb1, Ccnb2, Ccnf, Cdc23, Cdc25c, Cdc6, Cdca2, Cdca3, Cdca5, Cdca8, Cenpe, Cenpf, Cenph, Cep55, Cit, Ckap5, Ercc6l, F630043A04Rik, Fam83d, Haus1, Haus5, Hells, Incenp, Kif11, Kif18a, Kif20b, Kntc1, Ncapd2, Mlh1, Myh10, Myo5a, Ncapd3, Ncapg2, Ndc80, Nde1, Nek1, Nek2, Nsl1, Nuf2, Nup43, Nusap1, Oip5, Plk1, Plxna2, Pttg1, Sema6a, Sgol1, Ska1, Smc2, Spag5, Spc25, Tacc3, Timeless, Ube2c, Wee1, Zwilch
GO:0051640	Organelle localization
GO:0051303	Establishment of chromosome localization
GO:0006259	DNA metabolic process	3.51E-19	Atrip, Gadd45a, Giyd2, Sgk1	0610007P08Rik, Atad5, Atr, Bard1, Blm, Bnip3, Brca1, Brca2, Brip1, Ccdc111, Cdc45l, Cdc6, Chaf1a, Chaf1b, Chek2, Clspn, Dclre1b, Dclre1c, Dna2, Dscc1, Dtl, Eme1, Endog, Ercc2, Esco2, Exo1, Fam175a, Fancb, Fancd2, Fancg, Fanci, Gen1, Gins2, Hells, Hmgb2, Kif22, Lig1, Lin9, Mcm10, Mcm8, Mdc1, Mlh1, Mpg, Mre11a, Nasp, Neil3, Nek1, Orc3l, Parp2, Pms2, Pola1, Pola2, Pold3, Pole, Pole2, Polg, Poli, Polm, Polq, Pot1a, Prim1, Prim2, Pttg1, Rad18, Rad50, Rad51, Rad51ap1, Rad51c, Recql4, Rfc3, Rfc4, Rtel1, Timeless, Top2a, Trip13, Ttn, Uhrf1, Xrcc2, Xrcc5
GO:0006974	Response to DNA damage stimulus
GO:0006260	DNA replication
GO:0007017	Microtubule-based process	1.47E-08	Gadd45a, Klc1	Birc5, Brca1, Ccdc99, Cenpe, Ckap5, Cntrob, Espl1, Haus1, Haus5, Kif11, Kif14, Kif15, Kif16b, Kif18a, Kif18b, Kif20a, Kif20b, Kif22, Kif23, Kif2c, Kif4, Kif9, Mlh1, Nav1, Ndc80, Nde1, Nuf2, Nusap1, Psrc1, Spc25, Stmn1, Tacc3, Tpx2, Tubd1, Tube1
GO:0000910	Cytokinesis	2.42E-06	–	Anln, Aurkb, Birc5, Brca2, Cit, Cntrob, Incenp, Myh10, Nusap1 Prc1, Racgap1
GO:0048168	Regulation of neuronal synaptic plasticity	1.48E-05	Camk2a, Hras1, Snca	Bhlhe40, Dlg4, Egr2, Grik2, Nf1, Rims1, Syngr1
GO:0006796	Phosphate metabolic process	5.74E-05	Bmp2k, Camk2a, Cdc2l1, Dclk3, Dusp1, Dusp14, Epha4, F2r, Gadd45g, Gnptab, Lpar3, Lyn, Map3k14, Mast2, Nrbp2, Pink1, Ppm1l, Ppp1cc, Prkci, Prkcq, Prkd1, Ptpn14, Ptprm, Sgk1, Snca, Snrk, Styk1, Tek, Tgfa, Tgfb2	AC102494.1, Acvrl1, Adrbk2, Atr, Aurka, Aurkb, B230120H23Rik, BC030499, Bub1, Bub1b, Ccnb1, Ccnd1, Cdc14a, Cdc25c, Cdc7, Cdkn3, Chek2, Cit, Dusp6, Dusp7, Fgf2, Fgfr1, Gsg2, Gyk, Ick, Map2k3, Mapk9, Mastl, Melk, Mertk, Mtm1, Nek1, Nek2, Pask, Pbk, Pdik1l, Pdk1, Pdp1, Plk1, Plk4, Prkd3, Ptpn6, Rps6ka1, Rps6ka6, Tnk2, Ttn, Ulk4, Vrk1, Vrk3, Wee1, Wnk3, Wnk4, Wnt5a
GO:0006323	DNA packaging	9.23E-05	Aifm2	Asf1b, Cdca5, Cenpa, H2afz, Hells, Hist1h1b, Hist1h2bl, Hist1h4c, Hist1h4d, Hjurp, Ncapd2, Ncapd3, Ncapg2, Nusap1, Smarca2, Smc2, Suv39h1, Top2a
In vivo
GO:0007155	Cell adhesion	6.90E-11	Adam23, Arvcf, Cadm4, Cdh13, Cdh19, Cdh26, Chl1, Col16a1, Col20a1, Col27a1, Col5a3, Ddr1, Dlg1, Fat4, Gpnmb, Hes1, Hspg2, Itga6, Itga7, Itgav, Itgb8, Lama2, Lamb1-1, Mcam, Megf10, Msln, Nid1, Npnt, Nrcam, Pcdh10, Pcdh20, Ptprf, Sorbs1, Sympk, Thbs4, Tnc, Ttyh1, Wnt7b	Acan, Adam12, Amigo2, App, Cd34, Cd36, Cd44, Cd93, Cdh3, Cdh5, Col12a1, Dchs1, Fbln5, Fn1, Lgals1, Lgals3bp, Pecam1, Ror2, Spp1, Tek, Wisp1
GO:0022610	Biologic adhesion
GO:0043062	Extracellular structure organization	2.68E-07	Adamts14, Cacna1a, Chrna1, Col5a3, Hspg2, Lrp4, Nid1, Npnt, Tnc, Vwa1, Wnt7b	Acan, Apbb2, App, Atp7a, Ccdc80, Col3a1, Fbln5, Lgals3, Mmp9, Nrg1, Serpinh1, Tfip11
GO:0030198	Extracellular matrix organization
GO:0042552	Myelination	1.87E-05	Erbb3, Gal3st1, Gjc3, Lgi4, Mbp, Nab2, Plp1, Pmp22, Pou3f1, Scd2, Sox10	Nrg1
GO:0007422	Peripheral nervous system dev.
GO:0030030	Cell projection organization	3.28E-05	Cacna1a, Ccdc88a, Chl1, Dclk1, Dnaic2, Fgd3, Fgd4, Gas7, Itga6, Kif3a, Lamb1-1, Mtap2, Nefl, Ngfr, Nrcam, Numb, Prkg1 Ptprz1, Rpl24, Rtn4rl2, Sema4f, Sema6c, Ttyh1, Tubb4	Apbb2, App, Atp7a, Clu, Lpar1, Slc11a2, Vav3
GO:0030031	Cell projection assembly
GO:0042325	Phosphorylation	5.68E-04	Ccdc88a, Cenpe, Dlg1, Fgd4, Gnai2, Lats2, Madd, Mdfic, Pdgfrb, Sh3bp5	App, Atp7a, Cd74, Dusp9, Egfr, Fabp4, Ghr, Hbb-b1, Hbb-b2, Lpar1, Map2k6, Map3k5, Nrg1, Prkce, Rgma, Spry1, Vav3
GO:0051338	Transferase activity
GO:0046578	Regulation of Ras protein signal transduction	1.91E-03	Arap3, Arhgef10l, Fgd3, Fgd4, Kalrn, Plekhg2, Tbc1d24	Evi5, Farp1, Git2, Iqsec2, Kras, Lpar1, Nrg1, Rabgap1, Spry1, Tbc1d1, Vav3
GO:0044271	Cellular nitrogen compound biosynthetic process	2.21 E-03	Adc, Adcy1, Atp6v0b, Hdc, Mipol1, Nmnat2, Ppox, Prodh, Qtrtd1, Rp2h	Adcy7, Asns, Atp1b1, Atp2a1, Atp5o, Atp7a, Bcat1, Ldhd, Nos3, Paics, Prps1l1, Psph, Qprt, Rora, Rrm2b, Slc11a2
GO:0006029	Proteoglycan metabolic process	2.43E-03	AC127554.1, Sgsh	Acan, Bgn, Csgalnact2, Glce, Spock3
GO:0021675	Nerve development	3.01 E-03	Erbb3, Hes1, Ngfr, Rpl24	Hoxb2, Hoxb3
GO:0021545	Cranial nerve development
GO:0001501	Skeletal system development	3.92E-03	Dlg1, Gja5, Gpnmb, Hspg2, Nab2, Pdgfrb, Smad3, Sox6	Acan, Acd, Atp7a, Col1a1, Fmn1, Hoxb2, Hoxb3, Lgals3, Mmp13, Mmp14, Mmp9, Mn1, Osr2, Ror2, Spp1
GO:0009628	Response to abiotic stimulus	4.12E-03	Bcl2l1, Brcc3, Cryab, Hspb7, Ngfr, Otop1 Ric8, Scara5, Sox2, Strbp, Tsc22d3	App, Col1a1, Dclre1c, Hmgn1, Kras, Mmp13, Mmp14, Obfc2a, Stx1a, Usp1
GO:0001568	Blood vessel development	8.31 E-03	Apoe, Ccbe1, Gja5, Hdac7, Itga7, Itgav, Plcd3, Prl2c2, Tnfsf12	AC158680.2, Anpep, Atp7a, Cdh5, Col1a1, Col3a1, Mmp14, Nos3, Sema3c, Sox18, Zfpm2
GO:0008088	Axon cargo transport	9.86E-03	Nefm, Klc1, Klc2	App