Table 4.

Multiple logistic regression analyses for IL1R2 and IL10 candidate gene markers

GMM Class Comparison	Predictor	Odds Ratio	Standard Error	95% CI	Z	p-value
No breast pain versus severe breast pain (n=116)	IL1R2 genotype	36.07	53.03	2.02, 643.37	2.44	0.015
	Pain in the breast prior to surgery	10.40	11.61	1.17, 92.75	2.10	0.036
	Severity of average postoperative pain	2.15	0.40	1.48, 3.10	4.05	<0.001
	Overall model fit: χ2 = 54.64, p <0.0001; R2 = 0. 4619
No breast pain versus severe breast pain (n=116)	IL10 Haplotype A8	0.21	0.16	0.05, 0.91	−2.08	0.037
	Pain in the breast prior to surgery	12.63	14.70	1.29, 123.61	2.18	0.029
	Severity of average postoperative pain	2.03	0.37	1.42, 2.91	3.88	<0.001
	Overall model fit: χ2 = 52.82, p <0.0001; R2 = 0.4466

Notes: Multiple logistic regression analysis of the no pain and the severe pain GMM classes based on rating of worst breast pain. For each model, the first three principal components identified from the analysis of ancestry informative markers as well as self-report race/ethnicity were retained in all models to adjust for potential confounding due to race or ethnicity (data not shown). Predictors evaluated in each model included genotype (IL1R2 rs11674595: TT + TC versus CC; IL10 haplotype A8 composed of rs3024505- rs3024498-rs3024496-rs1878672-rs1518111-rs1518110-rs3024491: zero, one, or two doses of the C-G-C-G-A-T-T haplotype), occurrence of pain in the breast prior to surgery, and severity of average postoperative pain.

Abbreviations: CI = confidence interval; GMM = growth mixture model; IL1R2 = interleukin 1 receptor, type 2; IL10 = interleukin 10