Table 1.
Oxygen uptake, carotid and femoral blood flow, arterial blood pressure, arterial blood gases and lactates before (baseline) and at the end of repetition of intravenous H2S infusions. Data are expressed as Mean±SD.
|
Control
(n=8) |
Methemoglobin
(n=7) |
|
|||
|---|---|---|---|---|---|
| Baseline | mean |
SD |
mean |
SD |
p* |
| Weight (kg) | 0.41 | 0.026 | 0.43 | 0.051 | NS |
| VO2 (ml/kg/min) | 11.7 | 1.9 | 12.7 | 2.3 | NS |
| Carotid BF (ml/min) | 8.6 | 2.8 | 8.3 | 2.5 | NS |
| Femoral BF (ml/min) | 5.5 | 1.8 | 4.1 | 1.7 | NS |
| Arterial BP (mmHg) | 82 | 17 | 80 | 12 | NS |
| PaO2 (mmHg) | 69 | 9 | 67 | 14 | NS |
| PaCO2 (mmHg) | 37 | 6 | 36 | 14 | NS |
| Blood lactates (mM) | 2.38 | 0.6 | 1.9 | 0.7 | NS |
| Repetition of H2S infusions | |||||
| N° repetitions | 4.8 | 1.4 | 4.3 | 1.5 | NS |
| CgH2S (μM) | 15.6 | 2.9 | 15.8 | 2.6 | NS |
| Cumulative dose (μM) | 36.6 | 12.3 | 33.4 | 12.6 | NS |
| Total duration of infusion (s) | 101.6 | 34.1 | 92.8 | 34.9 | NS |
| End H2S infusion | |||||
| VO2 nadir (ml/kg/min) | 4.4 | 1.0 | 4.8 | 1.4 | NS |
| O2 deficit nadir (ml) | -16 | 4.9 | -16.8 | 3.1 | NS |
| Carotid BF nadir (ml/min) | 2.4 | 1.7 | 2.1 | 1.6 | NS |
| Femoral BF nadir (ml/min) | 0.6 | 0.8 | 0.4 | 0.2 | NS |
| Arterial BP nadir (mmHg) | 44 | 11 | 37 | 9 | NS |
| PaO2 (mmHg) | 63 | 9 | 76 | 21 | NS |
| PaCO2 (mmHg) | 38 | 14 | 35 | 7 | NS |
| Blood lactates (mM) | 5.7 | 1.2 | 5.8 | 1.5 | NS |
VO2 = oxygen uptake; Carotid BF= Carotid Blood Flow; Femoral BF= Femoral Blood Flow; Arterial BP= Arterial Blood Pressure N° repetitions= number of repetitions of H2S infusion, CgH2S=Concentration of gaseous H2S in the blood; SD = Standard deviation;
*
ANOVA