Table 2.

Association of Serum Sclerostin with Coronary and Aortic Artery Calcification in Afro-Caribbean Men

Model	Odd Ratio (95% CI) for Calcification Prevalence#		Spearman Correlation Coefficient for Calcification Score
	CAC	AAC	CAC	AAC
1	1.95 (1.30–2.91)	0.96 (0.65–1.40)	0.2854	0.0816
2	1.74 (1.15–2.63)	0.73 (0.47–1.14)	0.2301	0.0018
3	1.76 (1.13–2.76)	0.64 (0.39–1.05)	0.2090	-0.0125
4	1.61 (1.02–2.53)	0.65 (0.39–1.10)	0.1701	0.0173

^#Odds ratios are shown as the effect per 1 SD greater serum sclerostin (15.6 pmol/L) Significant differences by CAC or AAC status are underlined (P<0.05) and bolded(P<0.01)

Model 1, Unadjusted

Model 2, Age adjusted

Model 3, Fully adjusted: Age + physical characteristics (total body fat (%), grip strength), lifestyle factors (ever smoked, alcohol consumption, walking), comorbidities (diabetes, hypertension), and cholesterol measures (LDL-c, HDL-c, triglycerides, statin use)

Model 4, Fully adjusted plus Kidney function: Model 3 + eGFR CAC: coronary artery calcification; AAC: aortic artery calcification; SOST: sclerostin