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Results of commonly used serology-based tests are inconclusive with regard to HIV infection status in participants with VISR. The tests may not differentiate between vaccine-induced antibodies and antibodies present as a result of an HIV infection. Trial participants with VISR may be incorrectly perceived as being HIV-positive. Because the person with vaccine-induced antibodies could still become infected with HIV, VISR-status may lead to delayed diagnosis of infection.
