Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Atherosclerosis. 2015 Jan 14;239(1):232–239. doi: 10.1016/j.atherosclerosis.2015.01.008

A. Perl’s iron stain (staining blue) in Hp 2-2 brachiocephalic plaque. 40X magnification of the plaque. Quantitation of multiple plaques is provided in supplementary Table 2 demonstrating significantly increased staining (both intensity and area of the plaque stained) in Hp 2-2 plaques.

B. Minimum fibrous cap thickness (μm)±SE measured over the entire length of the brachiocephalic plaque. The minimum fibrous cap thickness of the brachiocephalic plaque in Hp 2-2 DM mice was significantly decreased as compared to Hp 1-1 DM mice p=0.028 with no significant difference between Hp 1-1 and Hp 2-2 mice in the absence of DM, p=0.323). N denotes the number of brachiocephalic plaques in which a clearly discernable cap could be measured for mice of a particular genotype. In Hp 1-1 mice without DM the vast majority of plaques examined for this parameter (12) did not have a fibrous cap.

A. Perl’s iron stain (staining blue) in Hp 2-2 brachiocephalic plaque. 40X magnification of the plaque. Quantitation of multiple plaques is provided in supplementary Table 2 demonstrating significantly increased staining (both intensity and area of the plaque stained) in Hp 2-2 plaques.

B. Minimum fibrous cap thickness (μm)±SE measured over the entire length of the brachiocephalic plaque. The minimum fibrous cap thickness of the brachiocephalic plaque in Hp 2-2 DM mice was significantly decreased as compared to Hp 1-1 DM mice p=0.028 with no significant difference between Hp 1-1 and Hp 2-2 mice in the absence of DM, p=0.323). N denotes the number of brachiocephalic plaques in which a clearly discernable cap could be measured for mice of a particular genotype. In Hp 1-1 mice without DM the vast majority of plaques examined for this parameter (12) did not have a fibrous cap.