Table 1.
Selected characteristics of study sample at baseline exam by quintile of sICAM-l
| Quintile of sICAM-1 | |||||
|---|---|---|---|---|---|
|
| |||||
| Q1 (n=373) |
Q2 (n=373) |
Q3 (n=373) |
Q4 (n=373) |
Q5 (n=373) |
|
| sICAM-1 ng/mL (mean, SD) | 170.3 ± 35.3 | 230.8 ± 9.3 | 262.6 ± 9.6 | 296.7 ± 11.5 | 383.7 ± 78.4 |
|
| |||||
| Age (mean ± SD) | 58.1 ± 9.0 | 59.0 ± 9.6 | 59.1 ± 9.5 | 59.7 ± 9.6 | 59.6 ± 9.3 |
| Percent male | 46.6 | 49.9 | 44.8 | 40.8 | 41.8 |
| Race (%) | |||||
| White, non-Hispanic | 28.2 | 51.1 | 54.2 | 53.4 | 49.3 |
| African-American | 32.4 | 12.1 | 13.1 | 15.3 | 17.7 |
| Hispanic/Latino | 13.4 | 14.5 | 21.4 | 24.1 | 29.2 |
| Chinese-American | 26.0 | 22.3 | 11.3 | 7.2 | 3.8 |
| Education (%) | |||||
| Incomplete High School | 14.2 | 9.9 | 11.8 | 16.1 | 19.8 |
| Completed High School | 11.8 | 16.6 | 15.3 | 21.4 | 21.4 |
| Some College | 28.4 | 27.3 | 27.3 | 27.6 | 31.1 |
| Completed College | 23.1 | 20.4 | 17.4 | 14.2 | 15.0 |
| Graduate Degree | 22.3 | 25.5 | 27.9 | 20.7 | 12.7 |
| Height (mean ± SD) cm | 166.9 ± 9.5 | 168.2 ± 10.0 | 167.2 ± 9.9 | 165.8 ± 9.6 | 165.9 ± 9.9 |
| Weight (mean ± SD) lbs | 166.9 ± 39.5 | 166.8 ± 36.8 | 174.2 ± 38.1 | 177.9 ± 39.4 | 180.0 ± 38.2 |
| BMI (mean ± SD) kg/m2 | 27.0 ± 5.2 | 26.6 ± 4.5 | 28.2 ± 5.3 | 29.3 ± 5.9 | 29.7 ± 5.8 |
| Smoking status (%) | |||||
| Never | 51.5 | 53.4 | 48.8 | 43.4 | 32.4 |
| Former | 39.4 | 38.9 | 40.8 | 41.8 | 35.1 |
| Current | 9.1 | 7.8 | 10.5 | 14.7 | 32.4 |
| Pack-years (mean ± SD)* | 19.1 ± 20.8 | 23.9 ± 23.3 | 23.0 ± 22.9 | 23.4 ± 22.3 | 33.0 ± 32.7 |
| Cigarettes/day (mean ± SD)† | 11.4 ± 10.2 | 9.7 ± 7.5 | 8.4 ± 7.8 | 11.6 ± 10.6 | 16.4 ± 12.6 |
| Recent cold or flu, % (No) | 13.2 (49) | 13.0 (48) | 14.5 (54) | 15.5 (58) | 17.4 (64) |
| Oral steroid use, % (No) | 0.54 (2) | 0.54 (2) | 1.9 (7) | 0.27 (1) | 1.1 (4) |
| C-reactive protein (mg/L) | 3.0 ± 5.1 | 2.7 ± 6.0 | 3.0 ± 3.7 | 4.2 ± 5.7 | 5.6 ± 7.1 |
| Sphingomyelin | 43.9 ± 12.7 | 44.4 ± 13.2 | 44.9 ± 18.0 | 43.6 ± 12.3 | 44.9 ± 12.8 |
| sE-selectin, ng/mL (mean, SD) n=928‡ | 40.8 ± 20.5 | 45.1 ± 17.0 | 49.7 ± 21.7 | 52.2 ± 21.3 | 66.3 ± 30.2 |
| sVCAM1, ng/mL (mean, SD) n=1,054‡ | 633.1 ± 150 | 687.7 ± 193 | 728.8 ± 169 | 713.2 ± 194 | 765.5 ± 233 |
| sL-selectin, ng/mL (mean, SD) n=1,054‡ | 894.5 ± 195 | 893.7 ± 186 | 915.1 ± 182 | 950.8 ± 201 | 946.2 ± 196 |
| sP-selectin, ng/mL (mean, SD) n=1,100‡ | 25.9 ± 7.3 | 26.8 ± 9.1 | 28.4 ± 10.6 | 28.9 ± 10.3 | 31.6 ± 10.8 |
*
for 904 ever-smokers reporting pack-years.
†
for current smokers, n=278.
‡
sample size includes those in the MESA Lung Study with both adhesion molecules measured.