Table 4.
Predicted change in percent emphysema, FEV1 and FEV1/FVC by levels of sVCAM-1, sL-selectin and sP-selectin
| Change per SD-log adhesion molecule (95% CI) |
P-value | |
|---|---|---|
| Percent emphysema, change per 10 years*† | ||
| sVCAM-1 (n=1,932) | −0.024 (−0.18, 0.13) | 0.77 |
| sL-selectin (n=1,932) | 0.001 (−0.16, 0.16) | 0.99 |
| sP-selectin (n=2,025) | −0.001 (−0.15, 0.14) | 0.99 |
| FEV1 (mL), change per year*‡ | ||
| sVCAM-1 (n=1,771) | −0.33 (−2.80, 2.14) | 0.79 |
| sL-selectin (n=1,771) | −1.92 (−4.25, 0.41) | 0.11 |
| sP-selectin (n=1,858) | −0.52 (−2.78, 1.75) | 0.66 |
| FEV1/FVC (%), change per year* | ||
| sVCAM-1 (n=1,749) | 0.02 (−0.04, 0.07) | 0.56 |
| sL-selectin (n=1,749) | 0.01 (−0.04, 0.06) | 0.76 |
| sP-selectin (n=1,834) | −0.02 (−0.06, 0.03) | 0.52 |
*
The models shown are adjusted for age, sex, race, education, height, weight, cigarettes per day, pack-years and C-reactive protein
†
The model for percent emphysema is also adjusted for scanner model, voxel size, mAs, sex*time, race*time, pack-years*time and sphingomyelin
‡
The model for FEV1 is also adjusted for height2