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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Neurobiol Learn Mem. 2014 Dec 27;0:178–188. doi: 10.1016/j.nlm.2014.12.007

Figure 5. Early postnatal nicotine exposure alters acute nicotinic modulation of LTP at TA pathway.

Figure 5

(A) At TA synapses in hippocampal slices from saline-treated control mice (n=6), tetanus stimulation (100 pulses at 100 Hz) induced LTP; LTP induction was blocked in the presence of bath application of 1 µM nicotine (n=5). (B) In hippocampal slices from MN mice, bath application of nicotine failed to block the TA-LTP (n=6) that was induced by tetanus stimulation in the absence of nicotine (n=7). (C) MN treatment blocks the effect of nicotine on TA-LTP, as shown by the percent change in the slope of fEPSPs with and without bath nicotine, measured 50–55 min after tetanus stimulation. (A, B) LTP-inducing stimulation was delivered at the time indicated by the arrow, and nicotine administration is indicated by the horizontal bar. Traces above each graph are representative waveforms recorded before (black) and 50 min after (red) LTP-inducing stimulation in control and bath-nicotine-treated slices. Cont: control; Nic: nicotine. *p< 0.05.

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