Figure 1.
Helical wheel projection diagrams of GALA, pHLIP, MelP5, MelP5_Δ4 and MelP5_Δ6. Residues colored blue are hydrophobic, yellow are hydrophilic, red are anionic at neutral pH and purple are cationic at neutral and low pH. Below are the sequences of the five peptides. The red letters signify the acidic residues in GALA and pHlip, and the acidic residues inserted into the sequence of MelP5 to make MelP5_Δ4 (4 substitutions) and MelP5_Δ6 (6 substitutions).