A. Brain weights of adult male and female mice of the wild type and nNOS−/− strains following exposure to various doses of alcohol during development. Alcohol led to significant dose-dependent reductions in brain weight, but only in the nNOS−/− mice. Post-hoc statistical comparisons for this data set were conducted by comparing animals of the same genotype and sex.
B. Alcohol-induced brain weight reductions were significantly more severe in the nNOS−/− mice than in wild type at both the low (2.2 mg/g) and high (4.4 mg/g) alcohol doses. Because there were no sex differences in alcohol-induced brain weight reductions, data for the two sexes are combined.
* Significantly different from the no alcohol group of the same sex and genotype (p<0.05).
# Significantly different from the wild type group administered the same dose of alcohol (p<0.05).