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. Author manuscript; available in PMC: 2016 Feb 9.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Feb 9;39(2):221–231. doi: 10.1111/acer.12615

Figure 3. Alcohol caused more severe microencephaly in nNOS−/− mice than in wild type mice.

Figure 3

A. Brain weights of adult male and female mice of the wild type and nNOS−/− strains following exposure to various doses of alcohol during development. Alcohol led to significant dose-dependent reductions in brain weight, but only in the nNOS−/− mice. Post-hoc statistical comparisons for this data set were conducted by comparing animals of the same genotype and sex.

B. Alcohol-induced brain weight reductions were significantly more severe in the nNOS−/− mice than in wild type at both the low (2.2 mg/g) and high (4.4 mg/g) alcohol doses. Because there were no sex differences in alcohol-induced brain weight reductions, data for the two sexes are combined.

* Significantly different from the no alcohol group of the same sex and genotype (p<0.05).

# Significantly different from the wild type group administered the same dose of alcohol (p<0.05).