Table 4.
Genotype | Behavioral test 2,3,4 |
Neuron number by Brain Region | |||
---|---|---|---|---|---|
Cerebral cortex neurons |
CA3 Pyramidal cells |
CA1 Pyramidal cells |
Dentate Gyrus neurons |
||
Wild type | Open Field | NS | −0.322* | NS | NS |
Morris maze | NS | NS | NS | NS | |
PPI | NS | NS | NS | NS | |
nNOS−/− | Open Field | −0.320* | NS | −0.360* | −0.346* |
Morris maze | 0.444** | NS | 0.453** | NS | |
PPI | 0.301* | NS | 0.310* | NS | |
Wild type and nNOS−/− combined | Open Field | −0.370** | −0.394** | −0.350** | −0.418** |
Morris maze | 0.370** | 0.279** | 0.346** | 0.293** | |
PPI | 0.210* | 0.266* | 0.230* | 0.242* |
Numbers are Pearson Correlation Coefficients.
For the Open Field Test, the total number of lines crossed was analyzed. Thus, the negative correlation coefficients imply that, as the number of neurons increased, the number of lines crossed decreased.
For the Morris Water Maze, the percent time spent in the target quadrant during the probe trial was analyzed. The positive correlation coefficients imply that, as the number of neurons increased, the time spent in the target quadrant increased.
For the paired pulse inhibition test (PPI), the percent inhibition at 16 dB was analyzed. Thus, the positive correlation coefficients imply that, as the number of neurons increased, the percent inhibition in response to the prepulse increased.
Significant at the 0.05 level.
Significant at the 0.01 level.
NS = not significant.