Table 3.
Association of XRCC1 genotypes with esophageal cancer.
| Genotypes | Case N (%) |
Control N (%) |
χ 2 | OR (95% CI) | P | OR (95% CI)* | P * |
|---|---|---|---|---|---|---|---|
| Codon 194 | |||||||
| CC | 166 (46.6) | 187 (44.6) | Reference | 1.00 | — | — | — |
| TC | 159 (44.7) | 193 (46.1) | 0.24 | 0.93 (0.69, 1.25) | 0.62 | 0.91 (0.66, 1.26) | 0.57 |
| TT | 31 (8.7) | 39 (9.3) | 0.18 | 0.90 (0.53, 1.50) | 0.67 | 0.96 (0.55, 1.68) | 0.90 |
| CC + TC | 190 (53.4) | 232 (55.4) | 0.31 | 0.92 (0.69, 1.23) | 0.58 | 0.92 (0.68, 1.25) | 0.59 |
| C | 567 (67.7) | 491 (69.0) | Reference | 1.00 | — | — | — |
| T | 271 (32.3) | 221 (31.0) | 0.30 | 1.06 (0.86, 1.32) | 0.58 | 0.90 (0.76, 1.21) | 0.70 |
| Codon 399 | |||||||
| GG | 184 (48.5) | 223 (51.6) | Reference | 1.00 | — | — | — |
| GA | 166 (43.8) | 169 (40.7) | 1.39 | 1.19 (0.89, 1.59) | 0.24 | 1.14 (0.84, 1.57) | 0.40 |
| AA | 29 (7.7) | 30 (7.7) | 0.32 | 1.17 (0.68, 2.02) | 0.57 | 1.03 (0.57, 1.86) | 0.92 |
| GA + AA | 195 (51.5) | 199 (47.2) | 1.47 | 1.47 (0.22, 1.57) | 0.22 | 1.13 (0.83, 1.52) | 0.44 |
| G | 534 (70.4) | 615 (72.9) | Reference | 1.00 | — | — | — |
| A | 224 (29.6) | 229 (27.1) | 1.15 | 1.13 (0.91, 1.40) | 0.28 | 1.07 (0.85, 1.35) | 0.57 |
| −77T>C | |||||||
| TT | 310 (83.6) | 319 (77.2) | Reference | 1.00 | — | — | — |
| TC | 59 (15.9) | 92 (22.3) | 5.09 | 0.66 (0.46, 0.95) | 0.02 | 0.70 (0.48, 1.03) | 0.07 |
| CC | 2 (0.5) | 2 (0.5) | 0.22 | 1.03 (0.14, 7.35) | 0.64 | 0 | 1.0 |
| TC + CC | 61 (16.4) | 94 (22.8) | 4.92 | 0.67 (0.47, 0.96) | 0.03 | 0.69 (0.47, 1.01) | 0.06 |
| T | 679 (91.5) | 730 (88.4) | Reference | 1.00 | — | — | — |
| C | 63 (8.5) | 96 (11.6) | 4.37 | 0.70 (0.50, 0.98) | 0.04 | 0.70 (0.48, 1.00) | 0.05 |
*adjusted for age, gender, smoking, drinking, and family history of cancer.