Table 1. Monolayer transport assay across the MDCK-MDR1 cells.
Papp(A→B) (nm/s) | Papp(B→A) (nm/s) | Efflux Ratio | |
---|---|---|---|
AMP 5μM | 11.6±1.3 | 479.7±45.7 | 42.0±7.2 |
+10 μM VER | 49.2±12.8** | 496.0±11.4 | 10.6±2.8 |
+2 μM GF120918 | 359.2±105.6** | 335.3±86.0 | 0.9±0.1 |
+10 μM HZ08 | 266.6±94.5** | 427.9±81.8 | 1.7±0.2 |
VCR 1μM | 3.2±1.0 | 19.9±2.8 | 6.4±1.1 |
+10 μM VER | 8.7±2.9* | 18.7±6.5 | 2.1±0.3 |
+2 μM GF120918 | 10.1±2.1** | 11.8±1.8* | 1.2±0.1 |
+10 μM HZ08 | 10.9±2.9* | 15.3±4.6 | 1.5±0.7 |
Data are presented as mean±SD, n = 3, Significance levels
* P<0.05
** P<0.01
***P< 0.001.