Table 2. HZ08 inhibition of VER-stimulated P-gp ATPase activity.

	ATP	Fold stimulation
	pmol ATP consumed/ μg P-gp / min
Non-treated	17.18±7.14	/
VER(100μM)	78.04±1.38	4.54
+ HZ08 (0.625μM)	74.09±4.02	4.31
+ HZ08 (1.25μM)	73.10±1.34*	4.26
+ HZ08 (2.5μM)	69.42±1.31**	4.04
+ HZ08 (5μM)	66.82±0.87***	3.89
+ HZ08 (10μM)	63.11±1.71***	3.67
+ HZ08 (20μM)	55.21±0.43***	3.21
+ HZ08 (40μM)	41.25±3.00***	2.40
+ HZ08 (80μM)	34.48±1.56***	2.01

Data are presented as mean±SD, n = 3

*P<0.05

**P<0.01

***P< 0.001 compared to the value from VER single agent treatment wells.