Table 2. The orientation of somatic L1 and Alu insertions relative to nearby genes.
| cerebellum | frontal cortex | SVZ | DG | myocardium | |
|---|---|---|---|---|---|
| L1 | |||||
| Number of somatic L1 detected in genes (p-value*) | 842 (<0.001) | 236 (0.02) | 584 (0.001) | 1558 (<0.001) | 578 (0.01) |
| Number (%) of CO-oriented somatic L1 | 345 (40.97) | 97 (41.10) | 239 (40.92) | 644 (41.34) | 234 (40.48) |
| Number (%) of COUNTER-oriented somatic L1 | 497 (59.03) | 139 (58.90) | 345 (59.08) | 914 (58.66) | 344 (59.52) |
| Number of somatic L1 detected in 5 kB upstream gene (p-value*) | 92 (0.004) | 31 (0.002) | 74 (0.002) | 177 (<0.001) | 62 (0.032) |
| Number (%) of CO-oriented somatic L1 | 38 (41.30) | 20 (64.52) | 31 (41.89) | 88 (49.72) | 34 (54.84) |
| Number (%) of COUNTER-oriented somatic L1 | 54 (58.70) | 11 (35.48) | 43 (58.11) | 89 (50.28) | 28 (45.16) |
| Alu | |||||
| Number of somatic Alu detected in genes (p-value*) | 623 (NS) | 1028 (NS) | 609 (NS) | 1465 (0.013) | 589 (NS) |
| Number (%) of CO-oriented somatic Alu | 323 (51.85) | 497 (48.35) | 304 (49.92) | 691 (47.17) | 279 (47.37) |
| Number (%) of COUNTER-oriented somatic Alu | 301 (48.15) | 531 (51.65) | 305 (50.08) | 774 (52.83) | 310 (52.63) |
| Number of somatic Alu detected in 5 kB upstream gene (p-value*) | 67 (NS) | 105 (NS) | 61 (NS) | 105 (0.021) | 55 (NS) |
| Number (%) of CO-oriented somatic Alu | 29 (43.28) | 43 (40.95) | 32 (52.46) | 45 (42.86) | 25 (45.45) |
| Number (%) of COUNTER-oriented somatic Alu | 38 (56.72) | 62 (59.05) | 29 (47.54) | 60 (57.14) | 30 (54.55) |
*—p-value based on Monte-Carlo test, 1000 permutations (see Materials and Methods for details), NS—non-significant (p>0.05)