Table 2. QTL for atherosclerosis at the aortic arch identified by genome-wide single scan.
Chr | Peak (cM) | CI (cM) | Peak (Mb) | CI (Mb) | LOD | Significance | High Allele | Mode of Inheritance | |
---|---|---|---|---|---|---|---|---|---|
Female and Male | 2 | 68 | 61–73 | 137 | 123–148 | 7.0 | Significant | DBA | Additive |
10 | 26 | 17–52 | 51 | 30–101 | 5.1 | Significant | 129 | Additive | |
19 | 34 | 17–39 | 39 | 22–46 | 3.2 | Suggestive | 129 | Recessive | |
Male | 2 | 65 | 58–74 | 153 | 132–165 | 4.0 | Significant | DBA | Additive |
10 | 22 | 12–53 | 46 | 26–111 | 4.0 | Significant | 129 | Additive | |
19 | 33 | 16–39 | 43 | 25–48 | 3.1 | Suggestive | 129 | Recessive | |
Female | 2 | 72 | 36–74 | 132 | 51–134 | 3.3 | Suggestive | DBA | Additive |
Model of inheritance was determined according to allelic effect at the nearest marker of a QTL by performing linear regression using the additive and dominant/recessive models. Significant QTL are shown in bold letters. CI, 95% confidence interval.