Figure 1.

Collection sites and conception of this study. Samples were obtained from a wide variety of geographical locations (triangles). A subset of samples contained natural products where the producing symbiotic bacteria were already known (boxes). Also shown in boxes are phylogenetic trees of the top-10 bacteria found in each sample (see Supplementary Figure S2C for details). Within these top 10, the natural product-producing symbiont is a major representative. This information was compared with metabolomic and microbiome analysis from ascidians where the natural products and producing organisms are not known, with the purpose of understanding the global relationship between natural products and symbiotic bacteria in ascidians.