Table 6.
Subgroup analysis of centrally evaluated EGFR/HER2 status
| EGFR IHC | IHC 0 (n = 34) | IHC 1 + (n = 4) | IHC 2 + (n = 10) | IHC 3 + (n = 1) |
|---|---|---|---|---|
| ORR (%) (95 % CI) | 29 (14, 44) | 0 | 20 (0, 45) | 0 |
| HER2 IHC | IHC 0 (n = 2) | IHC 1 + (n = 2) | IHC 2 + (n = 16) | IHC 3 + (n = 30) |
|---|---|---|---|---|
| ORR (%) (95 % CI) | 0 | 0 | 13 (2, 38) | 33 (17, 53) |
| HER2 FISH | FISH negative (n = 4) | FISH positive (n = 43) | ||
|---|---|---|---|---|
| ORR (%) (95 % CI) | 0 | 28 (15, 44) |
EGFR epidermal growth factor receptor, FISH fluorescence in situ hybridization, HER2 human epidermal growth factor receptor 2, IHC immunohistochemistry, ORR overall response rate (CR; PR)