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Chronic cocaine increases FOXO3a binding to, and mRNA expression levels of, several of its downstream targets in NAc. A, qChIP for FOXO3a in NAc of mice treated chronically with cocaine or saline on several known downstream targets of FOXO3a (n = 5 or 6). B, qPCR analysis of NAc of mice treated chronically with cocaine or saline for FOXO3a downstream targets (n = 7 or 8). *p < 0.05.
