Table 4.
Function analysis of 204 down-regulated target genes of UPmiRs and 295 up-regulated target genes of DNmiRs in IPA "Canonical Pathways".
| Ingenuity Canonical Pathways | UPmiRs | DNmiRs | ||
|---|---|---|---|---|
| p value | Count | p value | Count | |
| Superpathway of Cholesterol Biosynthesis | 8.51E-06 | 5 | ||
| Glycogen Biosynthesis II (from UDP-D-Glucose) | 1.10E-03 | 2 | ||
| Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I | 2.09E-02 | 2 | ||
| Regulation of the Epithelial-Mesenchymal Transition Pathway | 4.57E-02 | 5 | 7.76E-02 | 6 |
| Leukocyte Extravasation Signaling | 5.50E-02 | 5 | 4.17E-03 | 9 |
| Integrin Signaling | 5.50E-02 | 5 | 7.59E-05 | 12 |
| PDGF Signaling | 1.98E-01 | 2 | 2.51E-04 | 7 |
| CXCR4 Signaling | 2.12E-01 | 3 | 3.02E-03 | 8 |
| PAK Signaling | 2.29E-01 | 3 | 2.57E-03 | 6 |
| p53 Signaling | 2.64E-01 | 3 | 4.27E-03 | 6 |
| IGF-1 Signaling | 2.64E-01 | 3 | 2.19E-05 | 9 |
| p70S6K Signaling | 3.54E-01 | 3 | 1.20E-02 | 6 |
| RhoA Signaling | 3.54E-01 | 3 | 2.95E-03 | 7 |
| Axonal Guidance Signaling | 4.68E-01 | 5 | 5.50E-04 | 17 |
| Molecular Mechanisms of Cancer | 5.28E-01 | 4 | 2.14E-03 | 14 |
| NRF2-mediated Oxidative Stress Response | 5.42E-01 | 2 | 1.86E-03 | 9 |
| STAT3 Pathway | 5.42E-01 | 1 | 1.78E-04 | 7 |
| TGF-P Signaling | 5.98E-01 | 1 | 7.08E-05 | 8 |
| Glioma Signaling | 6.35E-01 | 1 | 8.32E-04 | 7 |
| Actin Cytoskeleton Signaling | 6.76E-03 | 9 | ||
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 2.82E-04 | 11 | ||
| Protein Kinase A Signaling | 9.33E-04 | 15 | ||
| ERK/MAPK Signaling | 8.91E-03 | 8 | ||
| PTEN Signaling | 6.03E-04 | 8 | ||
| NF-κB Signaling | 5.37E-03 | 8 | ||
| Regulation of Actin-based Motility by Rho | 2.45E-03 | 6 | ||
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 8.13E-03 | 4 | ||
| Total number of UPmiR-targets: 29 | ||||
| Total number of DNmiR-targets: 76 | ||||