Table 3.
Six-month change in principal components analysis (PCA) factors associated with the 6-month change in LP/Lean, short physical performance battery (SPPB), and 400-m
| Component loadings | β ± SE | P-value | q-value | |
|---|---|---|---|---|
| Six-month change in LP/Lean | ||||
| AC Factor 4: Glutarylcarnitine | 0.94 | 1.5 ± 0.7 | 0.05 | 0.25 |
| AA Factor 13: N6-acetyllysine | 0.90 | −1.4 ± 0.7 | 0.05 | 0.25 |
| Dipeptide Factor 1: γ-glutamyBCAAs (leucine, isoleucine, valine), leucylleucine | 0.90, 0.88, 0.84, 0.41 | −1.4 ± 0.7 | 0.07 | 0.29 |
| FA Factor 5: Valerate | 0.94 | 1.3 ± 0.7 | 0.07 | 0.29 |
| Dipeptide Factor 8: N-acetylmethionine | 0.94 | −1.3 ± 0.7 | 0.08 | 0.29 |
| Six-month change in SPPB | ||||
| FA Factor 8: 3-carboxy-4-methyl-5-propyl-2-furanpropionate | 0.94 | 0.4 ± 0.2 | 0.01 | 0.25 |
| AA Factor 12: Serotonin | 0.95 | 0.4 ± 0.2 | 0.03 | 0.25 |
| Dipeptide Factor 9: γ-glutamyltyrosine | 0.92 | −0.3 ± 0.2 | 0.04 | 0.25 |
| AA Factor 17: Dimethylglycine | 0.90 | −0.3 ± 0.2 | 0.05 | 0.25 |
| AA Factor 2: Glycine, serine, asparagine, alanine, glutamine | 0.90, 0.79, 0.71, 0.53, 0.47 | 0.3 ± 0.2 | 0.08 | 0.29 |
| Dipeptide Factor 10: Leucylphenylalanine | 0.90 | −0.3 ± 0.2 | 0.09 | 0.29 |
| AA Factor 14: N-acetyl-β-alanine | 0.93 | −0.3 ± 0.2 | 0.09 | 0.29 |
| Six-month change in 400-m | ||||
| AA Factor 8: Indoleacetate | 0.93 | −0.1 ± 0.0 | 0.03 | 0.25 |
| AC Factor 5: Isobutyrylcarnitine | 0.93 | 0.1 ± 0.0 | 0.03 | 0.25 |
| AA Factor 5: p-cresol sulfate, 3-indoxyl sulfate | 0.88, 0.81 | 0.1 ± 0.0 | 0.05 | 0.25 |
BCAA, branched-chain amino acids; LP/Lean, leg press one repetition maximum divided by total lean mass.
Sex, age, 6-month fat change (LP/Lean model) or 6-month BMI change (SPPB, 400-m models), whey/placebo group designation, and baseline function (for each respective model)-adjusted associations between the 6-month change in PCA factors with the 6-month change in LP/Lean, SPPB, and 400-m are shown with component loadings for metabolites contained within each respective PCA factor, parameter estimates and standard errors (β ± SE), in order of significance (P-value), and with q-values.