Table 5.
Top 20 pathways enriched in protein-coding genes that are co-expressed with the liver-related lncRNA HULC.
| Pahtway database |
Pahtway name | Background frequency | Sample frequency | P-value | Corrected P-value |
|---|---|---|---|---|---|
| Reactome | Metabolism | 1394/20447 | 128/390 | 6.17E-54 | 6.23E-51 |
| KEGG | Metabolic pathways | 1256/20447 | 109/390 | 7.95E-43 | 4.01E-40 |
| KEGG | Retinol metabolism | 69/20447 | 29/390 | 5.66E-32 | 1.91E-29 |
| KEGG | Complement and coagulation cascades | 87/20447 | 30/390 | 6.18E-30 | 1.56E-27 |
| EHMN | Androgen and estrogen biosynthesis and metabolism | 90/20447 | 30/390 | 2.02E-29 | 4.07E-27 |
| Reactome | Biological oxidations | 151/20447 | 36/390 | 2.71E-29 | 4.55E-27 |
| KEGG | Drug metabolism - cytochrome P450 | 76/20447 | 28/390 | 5.84E-29 | 8.41E-27 |
| KEGG | Metabolism of xenobiotics by cytochrome P450 | 87/20447 | 29/390 | 1.78E-28 | 2.24E-26 |
| KEGG | Chemical carcinogenesis | 86/20447 | 28/390 | 3.33E-27 | 3.74E-25 |
| EHMN | Tyrosine metabolism | 113/20447 | 30/390 | 4.29E-26 | 4.33E-24 |
| EHMN | Xenobiotics metabolism | 54/20447 | 23/390 | 9.33E-26 | 8.56E-24 |
| Reactome | Metabolism of amino acids and derivatives | 159/20447 | 32/390 | 1.09E-23 | 9.20E-22 |
| Wikipathways | metapathway biotransformation | 190/20447 | 34/390 | 2.43E-23 | 1.88E-21 |
| EHMN | Linoleate metabolism | 75/20447 | 24/390 | 2.81E-23 | 2.03E-21 |
| Wikipathways | cytochrome P450 | 68/20447 | 23/390 | 5.40E-23 | 3.63E-21 |
| Wikipathways | Complement and Coagulation Cascades | 60/20447 | 22/390 | 5.97E-23 | 3.77E-21 |
| EHMN | Leukotriene metabolism | 102/20447 | 26/390 | 2.87E-22 | 1.70E-20 |
| Reactome | Phase 1 - Functionalization of compounds | 74/20447 | 23/390 | 5.01E-22 | 2.81E-20 |
| KEGG | Drug metabolism - other enzymes | 53/20447 | 20/390 | 2.85E-21 | 1.51E-19 |
| Reactome | Xenobiotics | 15/20447 | 13/390 | 3.68E-21 | 1.86E-19 |