Table 1.
Metabolites were grouped into five clusters according to accumulation pattern.
| No. of Metabolites | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite Classa | ||||||||||
| In Group | AA | AR | eFA | fFA | OA | SGD | ST | UK | Total | P-Valueb |
| Cluster M1 | 3 | 4 | 9 | 1 | 2 | 9 | 23 | 29 | 80 | 0.00001 |
| Cluster M2 | 15 | 0 | 0 | 2 | 7 | 10 | 0 | 27 | 61 | 0.00005 |
| Cluster M3 | 0 | 0 | 3 | 1 | 3 | 11 | 4 | 14 | 36 | 0.03600 |
| Cluster M4 | 0 | 2 | 0 | 7 | 0 | 2 | 2 | 22 | 35 | 0.00005 |
| Cluster M5 | 13 | 1 | 0 | 1 | 3 | 9 | 1 | 33 | 61 | 0.00707 |
| All detected | 31 | 7 | 12 | 12 | 15 | 41 | 30 | 125 | 273 | |
| P-Valuec | 7.45E-07 | 0.092 | 3.99E-05 | 0.023 | 0.070 | 0.185 | 1.30E-12 | 0.073 | 2.30E-05 | |
aMetabolite Class: AA = Amino acids and Amines, AR = Aromatics, eFA = esterified Fatty Acid, fFA = free Fatty Acid, OA = Organic Acid, SGD = Sugars and Derivatives (alcohols and acids), ST = Sterols and Tocopherols, UK = Unclassified or Unknown.
bP-value, determined by Chi-square test, indicates whether the metabolites from the eight metabolite classes are distributed in each cluster in proportion to their distribution in the whole group. Significant p-values (alpha ≤ 0.05) are shown in bold.
cP-value, determined by Chi-square test, indicates whether the metabolites in each metabolite class are evenly distributed in each cluster. Significant p-values (alpha ≤ 0.05) are shown in bold.