Table. 2. Top 50 down-regulated genes in SNU-C5 compared to SNU-769B.
| Probe Set ID | Gene Symbol | SNU- 769A | SNU- C4 | SNU- C5 | FC | GO Biological Process Term | GO Cellular Component Term | GO Molecular Function Term |
|---|---|---|---|---|---|---|---|---|
| 8101893 | ADH1C | 2263 | 1125 | 14 | -7.3 | alcohol metabolic process | cytoplasm | alcohol dehydrogenase activity, zinc-dependent |
| 7989501 | CA12 | 2428 | 789 | 26 | -6.5 | one-carbon compound metabolic process | membrane | carbonate dehydratase activity |
| 8022692 | DSC3 | 904 | 35 | 10 | -6.5 | cell adhesion | membrane fraction | calcium ion binding |
| 7979658 | GPX2 | 2129 | 1408 | 24 | -6.5 | response to oxidative stress | cytoplasm | glutathione peroxidase activity |
| 7919055 | HMGCS2 | 2091 | 1229 | 28 | -6.2 | acetyl-CoA metabolic process | mitochondrion | hydroxymethylglutaryl-CoA synthase activity |
| 8036591 | LGALS4 | 5079 | 4762 | 69 | -6.2 | cell adhesion | cytosol | sugar binding |
| 7928770 | PCDH21 | 1522 | 291 | 21 | -6.2 | homophilic cell adhesion | membrane | calcium ion binding |
| 7953200 | CCND2 | 2210 | 60 | 37 | -5.9 | regulation of progression through cell cycle | nucleus | protein binding |
| 7928766 | C10orf99 | 1970 | 493 | 33 | -5.9 | |||
| 8138392 | AGR3 | 292 | 174 | 6 | -5.7 | |||
| 7919984 | SELENBP1 | 2409 | 1499 | 54 | -5.5 | selenium binding | ||
| 8174654 | KLHL13 | 650 | 164 | 16 | -5.3 | protein binding | ||
| 7967107 | C12orf27 | 367 | 229 | 9 | -5.3 | |||
| 8161884 | PRUNE2 | 396 | 230 | 12 | -5.1 | |||
| 8106354 | IQGAP2 | 704 | 95 | 22 | -5.0 | signal transduction | intracellular | actin binding |
| 8134339 | PEG10 | 658 | 28 | 21 | -5.0 | negative regulation of transforming growth factor beta receptor signaling pathway | cytoplasm | nucleic acid binding |
| 8135378 | PRKAR2B | 543 | 85 | 18 | -4.9 | protein amino acid phosphorylation | cAMP-dependent protein kinase complex | nucleotide binding |
| 8091283 | PLOD2 | 358 | 98 | 13 | -4.8 | protein modification process | endoplasmic reticulum | iron ion binding |
| 8128123 | RRAGD | 311 | 58 | 12 | -4.7 | nucleus | nucleotide binding | |
| 7983606 | EID1 | 759 | 568 | 30 | -4.7 | negative regulation of transcription from RNA polymerase II promoter | cellular component | protein binding |
| 8100734 | UGT2B17 | 125 | 6 | 5 | -4.6 | metabolic process | membrane fraction | glucuronosyltransferase activity |
| 8080964 | PPP4R2 | 293 | 130 | 12 | -4.6 | protein modification process | centrosome | protein binding |
| 8151592 | CA1 | 256 | 23 | 11 | -4.6 | one-carbon compound metabolic process | cytoplasm | carbonate dehydratase activity |
| 8101757 | GPRIN3 | 711 | 256 | 31 | -4.5 | |||
| 7926545 | PLXDC2 | 499 | 87 | 22 | -4.5 | multicellular organismal development | membrane | receptor activity |
| 7916185 | ZCCHC11 | 266 | 262 | 12 | -4.5 | intracellular | nucleic acid binding | |
| 8008172 | B4GALNT2 | 693 | 38 | 30 | -4.5 | UDP-N-acetylgalactosamine metabolic process | membrane | acetylgalactosaminyltransferase activity |
| 8040374 | FAM84A | 998 | 492 | 44 | -4.5 | |||
| 8168589 | ZNF711 | 378 | 106 | 19 | -4.4 | regulation of transcription, DNA-dependent | intracellular | DNA binding |
| 8043981 | IL1R2 | 663 | 54 | 33 | -4.3 | immune response | membrane | receptor activity |
| 7923578 | FMOD | 359 | 74 | 18 | -4.3 | transforming growth factor beta receptor complex assembly | proteinaceous extracellular matrix | protein binding |
| 8138553 | FAM126A | 210 | 69 | 11 | -4.3 | biological process | cellular component | signal transducer activity |
| 8077323 | CNTN4 | 168 | 11 | 10 | -4.1 | cell adhesion | plasma membrane | protein binding |
| 7999553 | FLJ11151 | 337 | 207 | 20 | -4.1 | hydrolase activity | ||
| 7940565 | FADS2 | 502 | 380 | 31 | -4.0 | lipid metabolic process | membrane fraction | iron ion binding |
| 7951554 | RDX | 259 | 67 | 16 | -4.0 | cytoskeletal anchoring | cytoplasm | actin binding |
| 8044212 | SULT1C2 | 215 | 39 | 13 | -4.0 | amine metabolic process | cytoplasm | sulfotransferase activity |
| 7903742 | GSTM2 | 946 | 183 | 59 | -4.0 | metabolic process | glutathione transferase activity | |
| 7937335 | IFITM1 | 402 | 343 | 25 | -4.0 | regulation of progression through cell cycle | plasma membrane | receptor signaling protein activity |
| 8041383 | LTBP1 | 470 | 213 | 30 | -4.0 | biological process | proteinaceous extracellular matrix | transforming growth factor beta receptor activity |
| 8142171 | SLC26A3 | 185 | 18 | 12 | -4.0 | transport | membrane fraction | transcription factor activity |
| 7951789 | FAM55D | 318 | 209 | 21 | -3.9 | |||
| 8078544 | MLH1 | 155 | 121 | 10 | -3.9 | mismatch repair | nucleus | single-stranded DNA binding |
| 8111772 | DAB2 | 344 | 72 | 23 | -3.9 | cellular morphogenesis during differentiation | coated pit | protein C-terminus binding |
| 8094988 | FLJ21511 | 270 | 75 | 18 | -3.9 | |||
| 7918223 | C1orf59 | 122 | 101 | 8 | -3.9 | |||
| 8095110 | KIT | 160 | 29 | 11 | -3.9 | protein amino acid dephosphorylation | external side of plasma membrane | nucleotide binding |
| 8125149 | SLC44A4 | 1306 | 1163 | 88 | -3.9 | membrane | ||
| 8178653 | NEU1 | 1306 | 1163 | 88 | -3.9 | metabolic process | lysosome | exo-alpha-sialidase activity |
| 8179861 | NEU1 | 1306 | 1163 | 88 | -3.9 | metabolic process | lysosome | exo-alpha-sialidase activity |
FC: Fold-change was calculated from the signal Log ratio value.