Table. 3. Histopathological findings for the SD rats during the 4-week recovery period study.
| Organ/findings | Sex | Male | Female | |||
|---|---|---|---|---|---|---|
| Group | G1 | G4 | G1 | G4 | ||
| Dose (mg/kg) | 0 | 0.28 | 0 | 0.28 | ||
| Number of animals | 5 | 5 | 5 | 5 | ||
| Adrenal | Fatty degeneration, zona fasciculata, bilateral | ± | 1 | 1 | 0 | 0 |
| Kidney | Basophilic tubules, focal, cortex | ± | 1 | 1 | 0 | 0 |
| Liver | Cell infiltration, mononuclear, focal | ± | 1 | 0 | 0 | 1 |
| Cell infiltration, mononuclear, focal | + | 0 | 0 | 1 | 0 | |
| Microgranuloma | ± | 0 | 0 | 0 | 1 | |
| Lung | Appearance, macrophages | + | 1 | 0 | 0 | 0 |
| with bronchi | Mononuclear cell, focal, around respiratory bronchiole | |||||
| Mineralization, arterial wall, focal | ± | 2 | 0 | 1 | 0 | |
| Pancreas | Proliferation, ductular cell, focal | + | 1 | 0 | 0 | 0 |
| Salivary gland, sublingual | Cell infiltration, mononuclear, periductular | ± | 0 | 0 | 1 | 0 |
| Thymus | Cyst | <+> | 0 | 0 | 1 | 1 |
| Thyroid | Hyperplasia, focal, follicular, right | + | 1 | 0 | 0 | 0 |
Grade- ±: minimal, +: mild <+>: presence in “presence or not” basis. There were no remarkable changes in the brain, cecum, colon, duodenum, epididymis (male), esophagus, eye, femur, harderian glands, heart, ileum, jejunum, mammary gland, mesenteric lymph node, ovary (female), parathyroid, pituitary, prostate (male), rectum, salivary gland (parotid, submandibular), seminal vesicle (male), skin, spinal cord, spleen, sternum, stomach, submandibular lymph node, testis (male), left or right thigh muscle (injection site), tongue, trachea, urinary bladder, uterus (female) and vagina (female) of the control and 0.28 mg/kg groups.