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. 2015 Jan 15;9(Suppl 2):S1. doi: 10.1186/1753-6561-9-S2-S1

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Copyright © 2015 Gari et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Multipotent haematopoietic stem cell pathway associated with the production of different blood cell lineages. The highlighted gene in colour is associated with neutrophil production (SCF, TPO, G-CSF, IL-3, IL-5). These genes need to be investigated further to screen for any mutations that could result in an aberrant gene which could inhibit the synthesis of neutrophils leading to a lower neutrophil count. EPO (erythropoietin - cytokine), G-CSF (colony stimulating factor 3 (granulocyte) - cytokine), GM-CSF (colony stimulating factor 2 (granulocyte-macrophage) – cytokine), IL-15 (interleukin 15 – cytokine), IL-2 interleukin 2 – (cytokine), IL-3 interleukin 3 – (cytokine), IL-4 (interleukin 4 – (cytokine), IL-5 (IL-5 interleukin 5 – (cytokine), IL-7 (interleukin 7 – (cytokine), M-CSF colony stimulating factor 1 (macrophage) - cytokine, SCF (KIT ligand) – growth factor, TPO (thrombopoietin) – cytokine.