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. 2014 Dec 30;38(2):130–137. doi: 10.14348/molcells.2015.2146

Fig. 5.

Fig. 5.

Knock-down of CCND1 phenoco- pied the effect of miR-576-3p. (A) Knockdown of miR-576-3p suppressed bladder cancer cell growth. The 50 nM of SiCCND1 caused significant cell viability inhibition in T24 and UM-UC-3 cells 48 h after transfection (*P < 0.05). (B) SiCCND1 reduced the colony formation rate in both of the cells (Representative wells were presented) (*P < 0.05). (C, D) Knock-down of CCND1 induced significant accumulation of cells in G1 phase (Representative histograms were shown above. The indicated percentages were means of triplicate experiments) (*P < 0.05). (E, F) Knock-down of CCND1 reduced the expression of CCND1 at the mRNA and protein levels in both two cell lines (*P < 0.05).