Figure 5.

Multicellular model reproduces population behaviors in varying extracellular environments

1. A phase diagram showing the coordinated population firing rate spanning a range of cell densities and flow rates for the model (A) and experiments in macrofluidic dishes from Gregor et al (2010) (B), with the mean firing rate represented in color, and white vertical lines indicate nonlinear breaks in the x-axis.
2. Firing rates can also be considered as a function of the ratio between cell density and flow rate, ρ/J, as predicted by the model (C) and shown experimentally using macrofluidic dishes in Gregor et al (2010) (D). Low flow rates are not plotted in (D) because in this regime, the effect of extracellular PDE is non-negligible. Model firing rates are normalized to an arbitrarily high frequency (˜1/30) to scale maximum values to 1.

Source data are available online for this figure.