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. 2014 Dec 11;2(12):e12196. doi: 10.14814/phy2.12196

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Outline of experimental design and study endpoints. Lewis polycystic kidney (LPK) and Lewis rats were administered intraperitoneal vehicle or PDTC once daily (40 × 1) or twice daily (40 × 2) beginning at postnatal week 4, and were euthanized at week 11. Urine was collected for measurement of renal function at weeks 5, 7, and 10, and MR imaging was performed at weeks 5 and 10. Abbreviations: TKV, total kidney volume measurement by MRI.