Table 1.
Effects of PDTC on body weight, renal function, and proteinuria in Lewis and LPK rats.
| Parameter | Lewis+V N = 3 | Lewis+P(40 × 2)N = 4 | LPK+VN = 9 | LPK+P(40 × 1)N = 8 | LPK+P(40 × 2)N = 9 |
|---|---|---|---|---|---|
| BW at week 11 (g) | 234 ± 6 | 233 ± 17 | 223 ± 20 | 218 ± 9 | 216 ± 20 |
| CrCl/BW (fold‐change vs. Lewis+V) | 1 ± 0.1 | 0.8 ± 0.2 | 0.5 ± 0.1* | 0.5 ± 0.1 | 0.5 ± 0.2 |
| Urine Pr:Cr (mg/mmol) | |||||
| Week 5 | ND | ND | 3 ± 6 | 19 ± 49 | 4 ± 7 |
| Week 7 | 15 ± 26 | ND | 12 ± 13 | 8 ± 13 | 55 ± 95 |
| Week 10 | 2 ± 4 | 20 ± 24 | 254 ± 166** | 108 ± 52 | 87 ± 52† |
| 24‐h urine volume (mL) | |||||
| Week 5 | 2 ± 1 | 5 ± 2 | 2 ± 1 | 3 ± 1 | 3 ± 1 |
| Week 7 | 10 ± 4 | 10 ± 3 | 10 ± 4 | 9 ± 3 | 10 ± 5 |
| Week 10 | 6 ± 2 | 8 ± 4 | 25 ± 4** | 24 ± 8 | 22 ± 5 |
| Serum urea (mmol/L) | 10 ± 6 | 8 ± 2 | 15 ± 2 | 15 ± 4 | 15 ± 4 |
| Serum Cr (μmol/L) | 25 ± 2 | 31 ± 8 | 46 ± 5* | 49 ± 9 | 46 ± 9 |
| Serum Albumin (g/L) | 27 ± 4 | 27 ± 2 | 26 ± 2 | 23 ± 2‡ | 25 ± 2 |
| HW:BW (%) | 3.3 ± 0.3 | 3.0 ± 0.1 | 4.8 ± 0.3** | 5.2 ± 0.4 | 4.6 ± 0.6 |
BW, body weight; Cr, creatinine; CrCl/BW, creatinine clearance corrected for body weight; HW:BW, heart weight to body weight ratio; LPK, Lewis polycystic kidney; ND, not detected; P(40 × 1), PDTC 40 mg/kg once daily; P(40 × 2), PDTC 40 mg/kg twice daily; Pr:Cr, urinary protein to creatinine ratio; V, vehicle.
Data expressed as mean ± SD.
*P < 0.05 versus Lewis + vehicle, **P < 0.01 versus Lewis + vehicle, †P < 0.05 versus LPK + vehicle, ‡P < 0.01 versus LPK + vehicle.