Figure 5.

Increased expression and phosphorylation of NCC do not increase arterial blood pressure in Fxyd2^−/− mice under basal conditions. Males (gray background) and females (white background) of WT (open boxes) and knockout mice (patterned boxes) (n = 5–6 for each genotype) were subjected to blood pressure measurement by the tail‐cuff method. At least 10–20 cycles were averaged for each measurement. Data were analyzed by unpaired Student's t‐test producing two‐tailed P values < 0.001 and < 0.05 for males and females, respectively. The data show a slight reduction, not the predicted increase, in pressure. Data are presented as the means ± SEM.