Table 2.
Efficacy | Comparable to interferon beta-1a sc tiw in the TENERE study6 |
Route of administration | Oral |
Dosing frequency | Once daily |
Half-life | 19 days (median) |
Pharmacovigilance | Initially frequent liver enzyme controls (every 2 weeks) |
Side effects (selection only) | Arterial hypertension Gastrointestinal disorders (diarrhea, nausea) Hair thinning Hematological abnormalities (leucopenia, lymphopenia) Liver enzyme increase |
Abbreviations: MS, multiple sclerosis; sc, subcutaneous; TENERE, TErifluNomidE and REbif.®; tiw, three times weekly.