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. 2015 Feb 18;9:44. doi: 10.3389/fncel.2015.00044

Figure 5.

Figure 5

Computer simulations of minis according to a pre-docking 1/f hypothesis. Power-law analysis of minis generated according to 1/fα docking process and a spontaneous fusion phase whose timing followed an exponential distribution (mean parameter 1/λ). (A,B) Triangles plot α values estimated by PG (A panel) and AF (B panel) from simulated minis series. Triangles with the same color refer to simulations where α was computed for a fixed number of release sites (N; see lookup table on the right) while varying λ. Notice how increasing λ strongly enhances the value of α estimated by both PG and AF methods (for all N, λ = 0.1–8.7 s−1, p < 0.01 for αPG and αAF; Spearman correlation test). The fitted line shows an asymptotic growth profile reminiscent of what found in living synapses for α-LTX experiments (Figure 4E). (C,D) Triangles with the same color refer to simulations where α was computed for a fixed value of λ (see lookup table on the right) while varying the number of release sites N. α values were estimated by PG (C panel) and AF (D panel). Notice how despite the very large increase in the number of sites N, in these simulations no clear sign of correlation between α and N could be found (in 95/100, p ≥ 0.05 for αPG; in 89/100 p ≥ 0.05 for αAF; Spearman correlation test).