Table 5.

The PK/PD modeling parameters for sevoflurane.

	t1/2keo(min)	γ	Emax	Emin	EC50	R2
RE	0.04 ± 0.03	8.25 ± 7.62	0.46 ± 0.09	0.13 ± 0.06	1.19 ± 0.60	0.80 ± 0.14
SE	0.06 ± 0.06	5.22 ± 2.32	0.35 ± 0.09	0.14 ± 0.05	1.71 ± 0.93	0.72 ± 0.16
SWE	0.07 ± 0.02	4.01 ± 3.12	1.01 ± 0.16	0.15 ± 0.07	1.42 ± 0.51	0.79 ± 0.12
TWE	0.03 ± 0.01	3.81 ± 1.86	0.50 ± 0.10	0.05 ± 0.16	1.54 ± 0.63	0.86 ± 0.06
RWE	0.04 ± 0.02	5.95 ± 3.98	0.58 ± 0.10	0.12 ± 0.07	1.68 ± 0.60	0.85 ± 0.06
HHSE	0.05 ± 0.02	4.15 ± 3.43	1.99 ± 0.41	0.62 ± 0.34	1.56 ± 1.15	0.80 ± 0.06
ApEn	0.05 ± 0.02	8.22 ± 6.62	0.82 ± 0.17	0.22 ± 0.11	1.84 ± 0.52	0.78 ± 0.11
SampEn	0.05 ± 0.02	5.68 ± 4.45	1.46 ± 0.38	0.40 ± 0.22	1.64 ± 0.62	0.75 ± 0.12
FuzzyEn	0.06 ± 0.04	2.75 ± 1.54	2.14 ± 0.40	0.58 ± 0.32	1.05 ± 0.38	0.69 ± 0.17
SPE	0.70 ± 0.32	4.65 ± 1.57	0.32 ± 0.05	0.08 ± 0.03	1.30 ± 0.33	0.94 ± 0.04
TPE	0.18 ± 0.01	6.98 ± 3.19	0.39 ± 0.04	0.02 ± 0.12	1.33 ± 0.37	0.96 ± 0.02
RPE	0.02 ± 0.01	4.67 ± 3.25	0.50 ± 0.14	0.10 ± 0.16	1.40 ± 0.48	0.95 ± 0.03
MDFA(2)	0.07 ± 0.03	4.92 ± 3.10	0.27 ± 0.15	1.37 ± 0.32	1.52 ± 0.49	0.88 ± 0.06
MDFA(-8)	0.05 ± 0.02	4.54 ± 2.57	0.03 ± 0.27	1.67 ± 0.14	1.33 ± 0.40	0.94 ± 0.03

t_1/2k_eo, blood effect-site equilibration constant; γ, slope parameter of the concentration-response relation; E_max, EEG parameter value corresponding to the maximum drug effect; E_min, EEG parameter value corresponding to the minimum drug effect; EC₅₀, concentration that causes 50% of the maximum effect; R², maximum coefficients of determination.