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. 2015 Feb 18;3:8. doi: 10.3389/fchem.2015.00008

Table 1.

Concentration at onset of contractile response, half maximal effective concentration or potency (EC50), and the maximal response or efficacy (EMAX) of ergot alkaloids in bovine lateral saphenous veinsa.

Alkaloid Onset (M)b EC50 (M) EMAX (%) Ergotamine equivalence level
Ergovaline 1 × 10−8 4.0 × 10−6 ± 1.5 × 10−6 104.1 ± 6.0 1
Ergotamine 1 × 10−8 4.0 × 10−6 ± 1.5 × 10−6 104.1 ± 6.0 1
Ergonovine 1 × 10−7 3.4 × 10−6 ± 8.8 × 10−7 68.5 ± 4.1 0.1
Ergocristine 1 × 10−7 5.6 × 10−6 ± 1.3 × 10−6 45.5 ± 4.5 0.1
Ergocornine 1 × 10−7 4.0 × 10−5 ± 2.3 × 10−5 57.2 ± 9.9 0.1
α-Ergocryptine 1 × 10−6 5.4 × 10−6 ± 1.2 × 10−6 42.9 ± 4.1 0.01
Lysergic acid 1 × 10−5 5.5 × 10−5 ± 2.3 × 10−5 22.6 ± 4.1 0.001
a

Taken from Klotz et al. (2006, 2007, 2010).

b

Expressed as a percent of norepinephrine maximum, which was a 1 × 10−4 M norepinephrine reference addition. Onset is normalized to the closest order of magnitude.