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. 2015 Feb 18;6:30. doi: 10.3389/fneur.2015.00030

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Copyright © 2015 Sandow, Kim, Raue, Päsler, Klaft, Antonio, Hollnagel, Kovacs, Kann, Horn, Vajkoczy, Holtkamp, Meencke, Cavalheiro, Pragst, Gabriel, Lehmann and Heinemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical experiments in slices from TCx-specimens. The traces were taken at the end of all subsequent protocol sequences (control, AED, AED + MDTIs, washout). (A) In sister-slices from the same specimen: S1 displaying resistance of SLEs against PHT and PHT + PBN + VPM; S2 illustrates resistance against PHT but transition of SLE to RET during co-administration (PHT + PBN + VPM); (B) in another specimen also displaying resistance of SLE against PHT but suppression of SLE during co-administration (PHT + PBN + VPM). The drugs applied are described above each pair of traces, which display [K⁺]_o (top) and field potential (FP) (bottom). Calibration bars for amplitude and time are given on the right.