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. 2015 Feb 18;6:30. doi: 10.3389/fneur.2015.00030

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Copyright © 2015 Sandow, Kim, Raue, Päsler, Klaft, Antonio, Hollnagel, Kovacs, Kann, Horn, Vajkoczy, Holtkamp, Meencke, Cavalheiro, Pragst, Gabriel, Lehmann and Heinemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summarized effects of unspecific inhibitors of P-glycoprotein (Pgp) and multi-drug resistance-associated proteins (MRPs). Categories of drug effects, marked by different colors, are shown on top of (A). (A) Proportional distribution of effects after administration of MDTIs in hippocampal and cortical slice-groups. (B) Circles representing the distribution of effects by probenecid (PBN), verapamil (VPM), and both PBN and VPM in hippocampal (top) and cortical slice-groups (bottom). (C) Corresponding averaged remaining normalized parameter values for event rate, AV3 (average of normalized values for sfp, peak, and duration), [K⁺]_o base, and ([K⁺]_o. Ordinates: (A) percentage of slices; (C) means ± SEM for percentages of control values. Signs for significant differences between proportional distributions *p ≤ 0.05, or ranges of values for PBN vs. PBN + VPM *p ≤ 0.05. Numbers in parenthesis give number of slices in sub-samples (A,B). The numbers in (B) also apply to (C).