Table 4.

Joint effect of depression variables and telomere length on mortality in bladder cancer patients in multivariate Cox regression analyses

	Alive, N(%)	Dead, N(%)	Adjusted HR (95% CI)*	P-value
Telomere and CES_D
Long telomere and CES-D<16	102(83.61)	20(16.39)	1(reference)
Short telomere and CES-D<16	103(83.06)	21(16.94)	0.96(0.49–1.88)	0.9064
Long telomere and CES-D≥16	29(74.36)	10(25.64)	1.16(0.50–2.70)	0.7343
Short telomere and CES-D≥16	19(55.88)	15(44.12)	3.96(1.86–8.41)	0.0003
Telomere and Lifetime MDD
Long telomere and MDD negative	33(82.50)	7(17.50)	1(reference)
Short telomere and MDD negative	25(89.29)	3(10.71)	1.36(0.31–5.93)	0.6860
Long telomere and MDD positive	102(80.95)	24(19.05)	1.70(0.65–4.47)	0.2834
Short telomere and MDD positive	103(74.64)	35(25.36)	2.24(0.88–5.75)	0.0923

^*Adjusted for age, gender, ethnicity, smoking status, grade and treatments by stage

Note: HR=Hazard Ratio; CI=Confidence Interval; MDD=Major Depression Disorder; CES-D= Center for Epidemiologic Studies Depression Scale.