Table 2.

Markers with FDR <0.05

Marker	FC	P-value	FDRq	Description&
Creatine Kinase MB*#$	6.52	<0.0001	<0.0001	cytoplasmic enzyme involved in energy homeostasis – cardiac isoenzyme
Tissue-type Plasminogen Activator*%	1.64	<0.0001	0.0002	serine protease involved in fibrinolysis, tumor angiogenesis, and myogenesis [29]
Myoglobin*#	2.23	0.0001	0.006	Iron-binding muscle protein
Epidermal Growth Factor*#	2.33	0.0004	0.01	Potent mitogenic factor, important role in the growth, proliferation and differentiation of numerous cell types.
Chemokine (C-C motif) ligand 2	1.48	0.0004	0.01	Recruits monocytes to sites of injury and infection.
CD40 Ligand*#	1.89	0.001	0.03	Expressed on the surface of T cells, regulates B cell function by engaging CD40
Vitronectin*#	1.28	0.001	0.03	Cell adhesion factor. Stabilizes PAI-1*. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

^&Descriptions taken from the Human Protein Reference Data Base, and NCBI gene reference

^*Markers with false discovery rate <5%

^#Log transformed for analysis.

^$Group estimates and statistical test from the GLM model adjusted for gender

^%Group estimates and statistical test from the GLM model adjusted for age

FC = fold change (positive FSH > control; negative control > FSH); FDR = false discovery rate