Fig. 1.

Schematic representations of human DDR1b and DDR2. The domain boundaries are indicated for the discoidin (DS) domain, the DS-like domain, the TM region, and the tyrosine kinase domain. The cell membrane is represented by a grey bar. The DDR1a splice variant lacks residues 506–542 (shown in orange). Predicted N- and O-linked glycosylation sites are indicated by magenta and green hexagons, respectively. Biochemically verified phosphorylation sites are shown in the cytoplasmic juxtamembrane regions and the activation loop of the tyrosine kinase domains. The overall sequence identity between human DDR1b and DDR2 is 52.8% (58.9% in the DS domain, 50.8% in the DS-like domain, 68.2% in the kinase domain).