Table 1.

Secondary structure analysis. Residues are assigned to the main secondary structure elements of the different NS conformers based on analysis of the crystallographic coordinates, MD simulations and CD data.

	α-Helix	β-Sheet	Other
Native	111 ± 3	108 ± 6	188 ± 7	in vitro1
	107 ± 7	115 ± 7	185 ± 14	in silico2
	100	118	189 ⁎	in crystal3
	116	119	172 ⁎	in crystal4
Cleaved	087 ± 2	139 ± 3	181 ± 4	in vitro1
	106 ± 7	135 ± 7	166 ± 14	in silico2
	108	145	154 ⁎	in crystal5
Latent	081 ± 2	138 ± 4	188 ± 5	in vitro1
	102 ± 6	125 ± 6	180 ± 12	in silico2
Polymer	094 ± 2	118 ± 4	195 ± 6	in vitro1

^⁎Including not resolved residues.

¹Calculated by CDPro from CD spectra.

²Calculated by STRIDE from MD simulation.

³Calculated by STRIDE from PDB ID: 3F5N[15].

⁴Calculated by STRIDE from PDB ID: 3FGQ[27].

⁵Calculated by STRIDE from PDB ID: 3F02[15].