Table 4. Effects of METH on subjective and physiological measures in the encoding group (n = 29).
| Measure | Placebo | 10 mg | 20 mg | Dose (F 1, 28) |
|---|---|---|---|---|
| Feel—DEQ | 1.37 (0.27) | 1.58 (0.27) | 2.75 (0.34)* | 15.02 |
| Like—DEQ | 1.63 (0.33) | 2.65 (0.44) | 4.12 (0.41)* | 28.86 |
| Dislike—DEQ | 1.28 (0.26) | 1.2 (0.24) | 1.23 (0.21) | 0.03 |
| High—DEQ | 1.09 (0.27) | 1.43 (0.28) | 2.09 (0.31)* | 9.22 |
| Take Again—DEQ | 2.82 (0.53) | 4.18 (0.49)* | 5.55 (0.46)* | 24.27 |
| Anxiety—POMS | -0.63 (0.47) | 0.02 (0.44) | -0.24 (0.38) | .41 |
| Elation—POMS | -1.94 (0.38) | -0.69 (0.48)* | 0.31 (.48)* | 11.7 |
| Fatigue—POMS | 0.79 (0.49) | -0.13 (0.37) | -0.44 (0.4) | 4.16 |
| Depression—POMS | -0.06 (0.13) | -0.29 (0.36) | -0.54 (0.5) | 0.94 |
| Confusion—POMS | 0.7 (0.28) | 0.01 (0.32) | 0.28 (0.3) | 1.36 |
| Vigor—POMS | -3.37 (.66) | -1.28 (0.71)* | -1.04 (0.7)* | 4.97 |
| Arousal—POMS | -5.49 (1.26) | -1.14 (1.06)* | -1.12 (1.21)* | 5.46 |
| Positive Mood—POMS | -1.88 (0.41) | -0.4 (0.71) | 0.85 (0.7)* | 10.83 |
| Systolic blood pressure (mmHg) | -3.32 (1.15) | 4.84 (1.04)* | 12.34 (1.99)* | 39.32 |
| Diastolic blood pressure (mmHg) | -1.25 (0.87) | 4.81 (0.76)* | 9.72 (1.04)* | 102.36 |
| Heart rate (bpm) | -4.56 (1.22) | 2.92 (.98)* | 5.54 (1.62)* | 25.61 |
Data are change from pre-TX baseline means (SEM) averaged across time from +20 to +320 min post-capsule (with the exception of the DEQ [which was not administered pre-TX], and corresponding F-values from one-way repeated measures ANOVA examining linear main effects of drug dose. Bold values indicate a significant linear main effect of drug dose (p<.05).
*p<.05 compared to placebo.