Table 5. Effects of METH on subjective and physiological measures in the consolidation group (n = 31).
| Measure | Placebo | 10 mg | 20 mg | Dose (F 1, 30) |
|---|---|---|---|---|
| Feel—DEQ | -0.4 (0.26) | -0.01 (0.3) | 0.8 (0.53) | 3.62 |
| Like—DEQ | -0.65 (0.28) | 0.4 (0.37)* | 1.42 (0.63)* | 8.98 |
| Dislike—DEQ | -0.61 (0.32) | -0.53 (0.38) | -0.11 (0.29) | 0.86 |
| High—DEQ | -0.12 (0.2) | 0.05 (0.29) | 0.66 (0.42) | 2.15 |
| Take Again—DEQ | -0.45 (0.26) | 0.89 (0.35)* | 1.9 (0.57)* | 16.26 |
| Anxiety—POMS | -0.14 (0.27) | -0.21 (0.85) | 1.74 (0.57)* | 7.78 |
| Elation—POMS | -0.09 (0.32) | 1.48 (0.5)* | 2.77 (0.66)* | 19.37 |
| Fatigue—POMS | 0.12 (0.39) | -1.21 (0.52) | -1.26 (0.58) | 3.05 |
| Depression—POMS | -0.16 (0.21) | -0.64 (0.22) | 0.01 (0.28) | 0.26 |
| Confusion—POMS | -1.4 (0.53) | -1.38 (0.5) | -1.64 (0.74) | 0.14 |
| Vigor—POMS | -0.3 (0.56) | 1.47 (0.57)* | 4.52 (1.06)* | 20.21 |
| Arousal—POMS | 0.84 (1.18) | 3.85 (1.42) | 9.15 (2.31)* | 15.21 |
| Positive Mood—POMS | 0.07 (0.4) | 2.12 (0.52)* | 2.77 (0.8)* | 12.71 |
| Systolic blood pressure (mmHg) | -2.23 (0.96) | 2 (1.13)* | 5.25 (0.94)* | 29.68 |
| Diastolic blood pressure (mmHg) | -0.64 (0.89) | 2.43 (0.82)* | 5.03 (0.83)* | 18.78 |
| Heart rate (bpm) | -2.86 (1.29) | 1.36 (0.91)* | 1.94 (0.81)* | 13.42 |
Data are change from pre-TX baseline means (SEM) averaged across time from +20 to +240 min post-capsule, and corresponding F-values from one-way repeated measures ANOVA examining linear main effects of drug dose. Bold values indicate a significant linear main effect of drug dose (p<.05).
*p<.05 compared to placebo.