Fig. 3.
Ad.5/3-CTV, but not Ad.5-CTV, induce ER stress and apoptosis, and overcome therapy resistance in PC-3-Bcl-2 tumor cells. A: Changes in BiP/GRP78, GRP94, and activation of PARP were detected by Western blot analysis after 2 days of treatment of PC-3 cells with the indicated Ads. B + C: Cell viability using the MTT assay was quantified after 6 days with the indicated doses of vp/cell of Ad.5-CTV, Ad.5/3-CTV, and their respective controls. Results are the mean ± SD (n = 3).*P < 0.05 with the Ad.5-vec 10,000 vp/cell-infected group.