Top graphs (a, c) show changes in active (red) and null (blue) electrochemical currents and bottom graphs (b, d) show changes in [glutamate] and [glucose], all at 2-s bins. In each case, a significant difference in substrate-sensitive versus Null currents (glutamate: Current × Time interaction F33,726=4.49; glucose: main effect F1,21=11.87, Current × Time interaction F33,693=3.03, all p<0.05) resulted in significant changes in concentrations vs. baseline (glutamate: F12,441=2.24, glucose: F11,407=3.39, both p<0.05). n defines number of tests in each group and filled symbols in b and d show values significantly different from the initial, quiet-rest baseline (Fisher LSD post-hoc test; p<0.05).