Top graphs show mean (±SEM) changes in currents (2-s bins) detected by glutamate, glucose and Null sensors (a, c) and bottom graphs show changes in [glutamate] (b) and [glucose] (d). While the changes in the glutamate versus Null currents and therefore [glutamate] were not significant (F11,1103=1.26; n.s.), glucose currents significantly differed from Null currents (Current × Time interaction F91,1911= 4.82; p<0.05) resulting in significant changes in [glucose] (F11,1103=5.32; p<0.05). Note that glucose rise was rapid, unimodal, transient, and followed by a robust decrease in its concentration below baseline. n defines number of tests in each group and filled symbols in b and d show values significantly different from the initial, quiet-rest baseline (p<0.05).