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. Author manuscript; available in PMC: 2015 Feb 18.
Published in final edited form as: Mol Cell Endocrinol. 2012 Jan 25;354(0):85–93. doi: 10.1016/j.mce.2012.01.002

Table 1.

General Comparison of Innate and Adaptive Immunity in Vertebrates.

Innate (Non-specific Immunity) Adaptive (Specific Immunity)
First line of defense Second line of defense
Cellular and secreted components: cytokines, chemokines, microbicides Humoral and Cell Mediated Protection
Response is antigen-independent Response is antigen-dependent
Immediate response Lag time between exposure and maximal response (antibody production)
Not antigen-specific Antigen-specific (Antibody specificity)
Exposure results in no immunologic memory, but can be enhanced after exposure to antigen through effects of cytokines Exposure results in immunologic memory