Table 3.

Summary of Immune Cells in the Human FRT including Location and Hormone Receptor Properties.

Cell Type	Location in FRT (*Indicates high cell numbers)	Major Immune Functions (Innate Immunity, II Adaptive immunity, AI)	ERα	ERβ	PR	References
Macrophage	Vagina, ectocervix endocervix*, uterus* (lymphocyte aggregates), Fallopian tubes	II. Phagocytosis, kill microorganisms and infected cells; Antigen presentation	++++	+	++	(Fahey et al. 2011; Janeway 2004; Khan, et al. 2005; Murphy, et al. 2009; Wira et al. 2010)
Neutrophils	Vagina, ectocervix endocervix*, uterus*	II. Phagocytosis, Antimicrobial α Defensins	+++	++	−	(Fahey et al. 2011; Janeway 2004; Moreno, et al. 2003; Wira et al. 2010)
Dendritic Cell	Vagina, ectocervix, endocervix*, uterus*	II. Antigen presenting cells (links adaptive and innate immune systems)	++	++	+	(Fahey et al. 2011; Janeway 2004; Komi and Lassila 2000; Wira et al. 2010)
Uterine NK cell	Vagina*, ectocervix -*, endocervix, uterus	II. Nonspecifically kill virus infected and tumor cells.	−	+++	++	(Arruvito, et al. 2008; Fahey et al. 2011; Henderson, et al. 2003; Janeway 2004; Wira et al. 2010)
CD4+ T Cells	Vagina, ectocervix, endocervix*, uterus*, Fallopian tubes *	AI. TH-1 cell mediated responses; IFN secretion – antiviral activity.	+++	++	+	(Fahey et al. 2011; Janeway 2004; Phiel, et al. 2005; Szekeres-Bartho, et al. 1990; Wira et al. 2010)
CD8+ (Cytotoxic T lymphocyte)	Vagina, ectocervix, endocervix*, uterus*, Fallopian tubes*	AI. TH-1 cell mediated responses; Apoptosis of infected cells	+	+++	+	(Fahey et al. 2011; Janeway 2004; Phiel et al. 2005; Szekeres-Bartho et al. 1990; Wira et al. 2010)
B cell	Vagina, ectocervix, endocervix, uterus (lymphocyte aggregate core), Fallopian tubes	AI. TH-2 Humoral responses; Maturation into IgA/IgG secreting plasma cells	+	++++	−	(Fahey et al. 2011; Janeway 2004; Phiel et al. 2005; Sapino, et al. 2003; Wira et al. 2010)