Figure 1. LRP1 protein was uniformly abundant in arterial vasculature, and its absence in SMCs did not lead to aortic pathologies in young mice.
A. Representative immunoblot of LRP1 protein abundance in ascending (Asc), thoracic (Thor), suprarenal (Supra), infrarenal (Infr) aorta, and superior mesenteric artery (SMA). β-actin was used as a loading control. Bar graph depicts LRP1/β-actin ratio quantified for each region. Histobars represent group means and errors are SEMs (n=4 per group). B. Representative immunoblot of vascular SMCs harvested from thoracic and abdominal aortas of smLRP1+/+ and -/- mice. β-actin was used as a loading control. C,D. Maximum suprarenal and ascending aortic diameter measured by ultrasound in 8 week old mice (n= 24 per group).